If there is particle matter in your cats urine, you will need to have a urinalysis done within two hours of excretion, since the casts will typically dissolve after two hours. ![]() In addition, urolithiasis is associated with AUTF in a substantial percentage of noninstrumented VU specimens. The medical term for this condition is cylindruria, and it is characterized by an abnormally high amount of particle matter (casts) in the urine sediment. In particular, the rate of high-grade urothelial carcinoma is significantly higher in noninstrumented VU specimens containing AUTF than those containing BUTF (8.8% vs 0.7% P<.0001). Of 72 cases without histopathologic, radiologic, or cytopathologic follow-up, 62 (86.1%) had a mean clinical follow-up of 22.5 months and 10 cases did not have clinical follow-up.ĬONCLUSIONS: The presence of AUTF in noninstrumented VU is associated with low rates of urothelial neoplasia but a statistically higher risk of urothelial neoplasia than the presence of BUTF (10.0% vs 4.4% P<.05). Twenty-five cases had follow-up cytology specimens, all of which were negative for malignancy. A total of 49 specimens (28.8%) were diagnosed with urolithiasis on follow-up. Twenty-four specimens had subsequent or coincidental surgical pathology specimens with the following overall rates of neoplasia: high-grade urothelial carcinoma: 8.8% (15 specimens), low-grade urothelial neoplasia: 1.2% (2 specimens), and prostate carcinoma invading the bladder: 0.6% (1 specimen). Possible causes of white particles, or sediment, in urine include: 1. RESULTS: A total of 170 noninstrumented VU specimens containing AUTF were identified. METHODS: The Johns Hopkins Hospital electronic pathology database was searched for VU cases containing UTF over a 5-year period. In this retrospective study, noninstrumented VU specimens containing UTF with atypical cytomorphological features (AUTF) were evaluated and compared with the previous results. The authors previously analyzed the outcome of patients with benign-appearing UTF in 274 noninstrumented VU specimens. If UTF contain cytomorphologically atypical cells, the diagnosis often becomes more challenging. The milk sugar alpha1H, which is found only in breast milk, breaks tumours into tiny fragments that cancer patients can pass in their urine without damaging healthy tissue (stock) The research has. ![]() Other studies had failed to reproduce similar results. ![]() In one study, tissue fragments were significantly more common in urine specimens from patients who had urothelial carcinoma on the follow-up histology than from patients who had negative biopsy results. Although most cytologists regard urothelial tissue fragments in voided urines (UTF) as abnormal, a recent review of such samples has found them commonplace and benign 11. BACKGROUND: The interpretation of urothelial tissue fragments (UTF) in voided urine (VU) specimens is controversial. The significance of cell clusters in voided urine is a controversial issue.
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